Methylation Decreases with Age
As we age, DNA methylation decreases, which results in the deterioration of our cells from a biological standpoint. When the methylation process slows down, our genes are more susceptible to disease and damage. Major factors that contribute to the demethylation process include our environmental pollution, smoking, and diet.
In more scientific terms, DNA methylation plays a crucial role in gene regulation and cell differentiation. We have known for a long time that DNA methylation is essential to genomic imprinting, which differentiates paternal and maternal alleles in mammals, but we now know it also assists in the X-chromosome inactivation, suppression of aging and carcinogenesis.